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AMG-337

CAT: 1410-M10584-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:1410-M10584-01Size:2 mg
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Description
AMG-337 is a potent and selective inhibitor of MET with biochemical IC50 of 1 nM; inhibits of HGF-mediated MET phosphorylation in PC3 cells.
CAS Number
1173699-31-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
463.4643
Molecular Formula
C23H22FN7O3
Notes
Research use only, not for human use.
Receptor
Met|Met (H1094R) |Met (M1250T) |Met (V1092I) |Met (Y1230H)

Chemical Information

Amg-337

AMG-337 is under investigation in clinical trial NCT03147976 (QUILT-3.036: AMG 337 in Subjects With Advanced or Metastatic Solid Tumors).

CAS Number1173699-31-4
PubChem CID44181686
IUPAC Name6-[(1R)-1-[8-fluoro-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5-one
Molecular FormulaC23H22FN7O3
Molecular Weight463.5
XLogP1.5
Topological Polar Surface Area99.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity760
SMILES
C[C@H](C1=NN=C2N1C=C(C=C2F)C3=CN(N=C3)C)N4C=CC5=C(C4=O)C=C(C=N5)OCCOC
InChI
InChI=1S/C23H22FN7O3/c1-14(30-5-4-20-18(23(30)32)9-17(11-25-20)34-7-6-33-3)21-27-28-22-19(24)8-15(13-31(21)22)16-10-26-29(2)12-16/h4-5,8-14H,6-7H2,1-3H3/t14-/m1/s1
InChIKey
DWHXUGDWKAIASB-CQSZACIVSA-N
Chemical Structure
2D Structure
2D structure of Amg-337
CAS: 1173699-31-4
CID: 44181686
Formula: C23H22FN7O3
MW: 463.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight463.5
XLogP31.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass463.17681575
Monoisotopic Mass463.17681575
Topological Polar Surface Area99.7 Ų
Heavy Atom Count34
Formal Charge0
Complexity760
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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204320AMG-337
441328-01AMG 337
A16400-2AMG 337 2mg
T70318-01AMG-337 monohydrate
A16400-100AMG 337 100mg
A16400-25AMG 337 25mg
A16400-10AMG 337 10mg
A16400-200AMG 337 200mg

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