INT-777

• Description:

  INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  450.65

• Molecular Formula:

  C27H46O5

• Notes:

  Research use only, not for human use.

• Receptor:

  GPCR19

• CAS Number:

  1199796-29-6