EGFR-IN-1 hydrochloride

• Description:

  EGFR-IN-1 hydrochloride is an irreversible and specific inhibitor of L858R/T790M mutant EGFR, with 100-fold selectivity over wild-type EGFR. It exhibits potent antitumor and antiproliferative activity in H1975 cells and mutant HCC827 cells with IC50s of 4 and 28 nM, respectively.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  551.04

• Molecular Formula:

  C28H31ClN6O4

• Notes:

  Research use only, not for human use.

• Receptor:

  EGFR

• CAS Number:

  2227455-78-7