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DB1976

CAT: 1410-M32877-07Size: 200 mgDry Ice: NoHazardous: No
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CAT#:1410-M32877-07Size:200 mg
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Description
DB1976 is a selenophene analog of DB270 and a highly potent, cell-permeable, fully efficacious transcription factor PU.1 inhibitor. It effectively inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, KD of 12 nM) in vitro. Additionally, DB1976 has an apoptosis-inducing effect.
CAS Number
1557397-51-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
447.35
Molecular Formula
C20H16N8Se
Notes
Research use only, not for human use.
Receptor
Apoptosis

Chemical Information

2,2'-(Selenophene-2,5-diyl)bis(1H-benzo[d]imidazole-6-carboximidamide)
CAS Number1557397-51-9
PubChem CID141655595
IUPAC Name2-[5-(6-carbamimidoyl-1H-benzimidazol-2-yl)selenophen-2-yl]-3H-benzimidazole-5-carboximidamide
Molecular FormulaC20H16N8Se
Molecular Weight447.4
Topological Polar Surface Area157
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity604
SMILES
C1=CC2=C(C=C1C(=N)N)NC(=N2)C3=CC=C([Se]3)C4=NC5=C(N4)C=C(C=C5)C(=N)N
InChI
InChI=1S/C20H16N8Se/c21-17(22)9-1-3-11-13(7-9)27-19(25-11)15-5-6-16(29-15)20-26-12-4-2-10(18(23)24)8-14(12)28-20/h1-8H,(H3,21,22)(H3,23,24)(H,25,27)(H,26,28)
InChIKey
NXECULIQZLOKFU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2,2'-(Selenophene-2,5-diyl)bis(1H-benzo[d]imidazole-6-carboximidamide)
CAS: 1557397-51-9
CID: 141655595
Formula: C20H16N8Se
MW: 447.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight447.4
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass448.06631
Monoisotopic Mass448.06631
Topological Polar Surface Area157 Ų
Heavy Atom Count29
Formal Charge0
Complexity604
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-135797DB1976
HY-135797A-01DB1976 (dihydrochloride)
GTR19206095-01DB1976 dihydrochloride

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