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DB1976

CAT: 0804-HY-135797Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-135797Size:1 Each
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Description
DB1976 is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, KD of 12 nM) in vitro. DB1976 has apoptosis-inducing effect[1][2][3].
CAS Number
1557397-51-9
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/db1976.html
Solubility
10 mM in DMSO
Smiles
N=C(C1=CC=C2N=C(C3=CC=C(C4=NC5=CC=C(C(N)=N)C=C5N4)[Se]3)NC2=C1)N
Molecular Formula
C20H16N8Se
Molecular Weight
447.35
References & Citations
[1]Munde M, et al. Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines. Nucleic Acids Res. 2014 Jan;42 (2) :1379-90.|[2]Stephens DC, et al. Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis. Nucleic Acids Res. 2016 May 19;44 (9) :4005-13.|[3]Antony-Debré I, et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest. 2017 Dec 1;127 (12) :4297-4313.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Neurochem Int. 2024 Feb:173:105674.|Cell Rep. 2024 Mar 26;43 (3) :113964.|Int J Biol Macromol. 2025 Sep;322 (Pt 1) :146515.|Nat Immunol. 2023 Nov;24 (11) :1839-1853.|Respir Res. 2023 Jan 25;24 (1) :32.

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