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ARRY-382

CAT: 1410-M28026-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M28026-06Size:100 mg
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Description
ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM.
CAS Number
1313407-95-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
564.68
Molecular Formula
C32H36N8O2
Notes
Research use only, not for human use.
Receptor
PDE10A

Chemical Information

Arry-382

cFMS Tyrosine Kinase Inhibitor ARRY-382 is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation.

CAS Number1313407-95-2
PubChem CID67259771
IUPAC NameN-[3-cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamide
Molecular FormulaC32H36N8O2
Molecular Weight564.7
XLogP3.9
Topological Polar Surface Area92.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Heavy Atom Count42
Formal Charge0
Complexity913
SMILES
CC1=NC(=CC=C1)CN2C3=CC=CC(=C3C(=N2)C4CC4)NC(=O)C5=CN=C6N5C=CC(=C6)OCCN7CCN(CC7)C
InChI
InChI=1S/C32H36N8O2/c1-22-5-3-6-24(34-22)21-40-27-8-4-7-26(30(27)31(36-40)23-9-10-23)35-32(41)28-20-33-29-19-25(11-12-39(28)29)42-18-17-38-15-13-37(2)14-16-38/h3-8,11-12,19-20,23H,9-10,13-18,21H2,1-2H3,(H,35,41)
InChIKey
JUPOTOIJLKDAPF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Arry-382
CAS: 1313407-95-2
CID: 67259771
Formula: C32H36N8O2
MW: 564.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight564.7
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Exact Mass564.29612242
Monoisotopic Mass564.29612242
Topological Polar Surface Area92.8 Ų
Heavy Atom Count42
Formal Charge0
Complexity913
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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