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PF-06952229

CAT: 1410-M26371-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M26371-06Size:100 mg
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Description
PF-06952229 is an selective and orally active inhibitor of TGFbR1.
CAS Number
1801333-55-0
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
458.92
Molecular Formula
C23H24ClFN4O3
Notes
Research use only, not for human use.
Receptor
MRP4| OAT1| OAT3

Chemical Information

4-((2-(5-Chloro-2-fluorophenyl)-5-isopropylpyridin-4-yl)amino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide

TGF-beta Receptor 1 Inhibitor PF-06952229 is an orally bioavailable inhibitor of transforming growth factor-beta receptor 1 (TGFbR1), with potential antineoplastic activity. Upon administration, TGF-betaR1 inhibitor PF-06952229 specifically targets and binds to TGFbR1, which prevents TGFbR1-mediated signal transduction. This abrogates TGFbR1-mediated immunosuppression, enhances anti-tumor immunity in the tumor microenvironment (TME) and promotes a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells leading to tumor cell death. This may lead to a reduction in TGFbR1-dependent proliferation of cancer cells. The TGFb signaling pathway is often deregulated in tumors and plays a key role in the regulation of cell growth, differentiation, apoptosis, motility, invasion, and angiogenesis. It plays a key role in immunosuppression in the TME.

CAS Number1801333-55-0
PubChem CID118211239
IUPAC Name4-[[2-(5-chloro-2-fluorophenyl)-5-propan-2-yl-4-pyridinyl]amino]-N-(1,3-dihydroxypropan-2-yl)pyridine-3-carboxamide
Molecular FormulaC23H24ClFN4O3
Molecular Weight458.9
XLogP3.4
Topological Polar Surface Area107
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Heavy Atom Count32
Formal Charge0
Complexity598
SMILES
CC(C)C1=CN=C(C=C1NC2=C(C=NC=C2)C(=O)NC(CO)CO)C3=C(C=CC(=C3)Cl)F
InChI
InChI=1S/C23H24ClFN4O3/c1-13(2)17-10-27-21(16-7-14(24)3-4-19(16)25)8-22(17)29-20-5-6-26-9-18(20)23(32)28-15(11-30)12-31/h3-10,13,15,30-31H,11-12H2,1-2H3,(H,28,32)(H,26,27,29)
InChIKey
IPBLCOKXDQHSQW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-((2-(5-Chloro-2-fluorophenyl)-5-isopropylpyridin-4-yl)amino)-N-(1,3-dihydroxypropan-2-yl)nicotinamide
CAS: 1801333-55-0
CID: 118211239
Formula: C23H24ClFN4O3
MW: 458.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight458.9
XLogP33.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass458.1520965
Monoisotopic Mass458.1520965
Topological Polar Surface Area107 Ų
Heavy Atom Count32
Formal Charge0
Complexity598
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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