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MK-6892

CAT: 1410-M22908-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:1410-M22908-03Size:10 mg
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Description
MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM) .MK-6892 evokes a potent internalization of GPR109A in U2OS β-arrestin2-RrGFP cells.MK-6892 shows an EC50 value of 74 nM on calcium mobilization assay.
CAS Number
917910-45-3
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
386.4
Molecular Formula
C19H22N4O5
Notes
Research use only, not for human use.
Receptor
GPR109A

Chemical Information

MK-6892

a niacin receptor agonist; structure in first source

CAS Number917910-45-3
PubChem CID135416394
IUPAC Name2-[[3-[3-(5-hydroxy-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanoyl]amino]cyclohexene-1-carboxylic acid
Molecular FormulaC19H22N4O5
Molecular Weight386.4
XLogP2.3
Topological Polar Surface Area138
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count28
Formal Charge0
Complexity636
SMILES
CC(C)(CC1=NC(=NO1)C2=NC=C(C=C2)O)C(=O)NC3=C(CCCC3)C(=O)O
InChI
InChI=1S/C19H22N4O5/c1-19(2,18(27)21-13-6-4-3-5-12(13)17(25)26)9-15-22-16(23-28-15)14-8-7-11(24)10-20-14/h7-8,10,24H,3-6,9H2,1-2H3,(H,21,27)(H,25,26)
InChIKey
CJHXBFSJXDUJHP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of MK-6892
CAS: 917910-45-3
CID: 135416394
Formula: C19H22N4O5
MW: 386.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight386.4
XLogP32.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass386.15901982
Monoisotopic Mass386.15901982
Topological Polar Surface Area138 Ų
Heavy Atom Count28
Formal Charge0
Complexity636
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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