HALOFUGINONE LACTATE

• Description:

  HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activityhalofuginone (HF), a widely studied derivative of febrifugine, inhibits the development of T (H) 17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. HF binds glutamyl-prolyl-tRNA synthetase (EPRS), inhibiting prolyl-tRNA synthetase activity; this inhibition is reversed by the addition of exogenous proline or EPRS.

• Stability:

  ≥ 2 years

• Purity:

  >98% (HPLC)

• Weight:

  504.8

• Molecular Formula:

  C19H23BrClN3O6

• Notes:

  Research use only, not for human use.

• Receptor:

  Prolyl-tRNA synthetase|TGF-β

• CAS Number:

  82186-71-8