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NSAH

CAT: 1410-M22882-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:1410-M22882-04Size:10 mg
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Description
NSAH is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR) .with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively.A unique nonnucleoside small-molecule hRR inhibitor, naphthyl salicylic acyl hydrazone (NSAH), using virtual screening, binding affinity, inhibition, and cell toxicity assays. NSAH binds to hRRM1 with an apparent dissociation constant of 37 µM, and steady-state kinetics reveal a competitive mode of inhibition.
CAS Number
1099592-35-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
306.3
Molecular Formula
C18H14N2O3
Notes
Research use only, not for human use.
Receptor
RR

Chemical Information

2-Hydroxy-1-naphthalaldehyde salicyloylhydrazone

structure given in first source

CAS Number1099592-35-4
PubChem CID135458654
IUPAC Name2-hydroxy-N-[(E)-(2-hydroxynaphthalen-1-yl)methylideneamino]benzamide
Molecular FormulaC18H14N2O3
Molecular Weight306.3
XLogP3.9
Topological Polar Surface Area81.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity440
SMILES
C1=CC=C2C(=C1)C=CC(=C2/C=N/NC(=O)C3=CC=CC=C3O)O
InChI
InChI=1S/C18H14N2O3/c21-16-8-4-3-7-14(16)18(23)20-19-11-15-13-6-2-1-5-12(13)9-10-17(15)22/h1-11,21-22H,(H,20,23)/b19-11+
InChIKey
ZZSJOLDICPVVAV-YBFXNURJSA-N
Chemical Structure
2D Structure
2D structure of 2-Hydroxy-1-naphthalaldehyde salicyloylhydrazone
CAS: 1099592-35-4
CID: 135458654
Formula: C18H14N2O3
MW: 306.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight306.3
XLogP33.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass306.10044231
Monoisotopic Mass306.10044231
Topological Polar Surface Area81.9 Ų
Heavy Atom Count23
Formal Charge0
Complexity440
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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