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Dimethylcurcumin

CAT: 1410-M22795-03Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M22795-03Size:1 mL x 10 mM in DMSO
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Description
Dimethylcurcumin (ASC-J9) is an androgen receptor degradation enhancer. It effectively suppresses castration-resistant prostate cancer cell proliferation and invasion.Dimethylcurcumin is able to degrade fAR and AR3 in a dose-dependent manner in various human PCa cells. Dimethylcurcumin can also effectively suppress AR-targeted genes in CWR22Rv1-fARKD cells.
CAS Number
52328-98-0
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
396.43
Molecular Formula
C23H24O6
Notes
Research use only, not for human use.
Receptor
Androgen Receptor

Chemical Information

Dimethylcurcumin

Dimethylcurcumin is an organic molecular entity. It has a role as an androgen antagonist.

CAS Number52328-98-0
PubChem CID6477182
IUPAC Name(1E,4Z,6E)-1,7-bis(3,4-dimethoxyphenyl)-5-hydroxyhepta-1,4,6-trien-3-one
Molecular FormulaC23H24O6
Molecular Weight396.4
XLogP4.6
Topological Polar Surface Area74.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Heavy Atom Count29
Formal Charge0
Complexity596
SMILES
COC1=C(C=C(C=C1)/C=C/C(=C/C(=O)/C=C/C2=CC(=C(C=C2)OC)OC)/O)OC
InChI
InChI=1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-15,24H,1-4H3/b9-5+,10-6+,18-15-
InChIKey
ZMGUKFHHNQMKJI-CIOHCNBKSA-N
Chemical Structure
2D Structure
2D structure of Dimethylcurcumin
CAS: 52328-98-0
CID: 6477182
Formula: C23H24O6
MW: 396.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight396.4
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Exact Mass396.15728848
Monoisotopic Mass396.15728848
Topological Polar Surface Area74.2 Ų
Heavy Atom Count29
Formal Charge0
Complexity596
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count3
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
TQ0214-01Dimethylcurcumin
HY-15194R-01Dimethylcurcumin (Standard)
C12072-25mgDimethylcurcumin (ASC-J9)
A11300-50Dimethylcurcumin (ASC-J9) 50mg
A11300-25Dimethylcurcumin (ASC-J9) 25mg
A11300-100Dimethylcurcumin (ASC-J9) 100mg
A11300-10Dimethylcurcumin (ASC-J9) 10mg
A11300-5Dimethylcurcumin (ASC-J9) 5mg
MBS132393-01ASC-J9 (GO-Y025, Dimethylcurcumin)
ESS0393-014',4"-O, O-Dimethylcurcumin

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