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SKI V

CAT: 1410-M21983-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:1410-M21983-05Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK, IC50 : 2 μM), and is a PI3K inhibitor (hPI3k, IC50 : 6 μM), induces apoptosis and has antitumor activity
CAS Number
24418-86-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
254.24
Molecular Formula
C15H10O4
Notes
Research use only, not for human use.
Receptor
SphK|PI3K

Chemical Information

(2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-1-benzofuran-3-one

3',4'-dihydroxyaurone is a hydroxyaurone that is aurone which is substituted by hydroxy groups at the 3' and 4' positions; major species at pH 7.3. It shows inhibitory activity against several isoforms of the histone deacetylase complex (HDAC). It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a member of catechols and a hydroxyaurone. It is functionally related to a 2',3,4-trihydroxy-trans-chalcone.

CAS Number24418-86-8
PubChem CID5793932
IUPAC Name(2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-1-benzofuran-3-one
Molecular FormulaC15H10O4
Molecular Weight254.24
XLogP2.9
Topological Polar Surface Area66.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count19
Formal Charge0
Complexity390
SMILES
C1=CC=C2C(=C1)C(=O)/C(=C/C3=CC(=C(C=C3)O)O)/O2
InChI
InChI=1S/C15H10O4/c16-11-6-5-9(7-12(11)17)8-14-15(18)10-3-1-2-4-13(10)19-14/h1-8,16-17H/b14-8-
InChIKey
HCBULGQMULJTCM-ZSOIEALJSA-N
Chemical Structure
2D Structure
2D structure of (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-1-benzofuran-3-one
CAS: 24418-86-8
CID: 5793932
Formula: C15H10O4
MW: 254.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight254.24
XLogP32.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass254.05790880
Monoisotopic Mass254.05790880
Topological Polar Surface Area66.8 Ų
Heavy Atom Count19
Formal Charge0
Complexity390
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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