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QO-40

CAT: 1410-M21936-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:1410-M21936-02Size:25 mg
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Description
QO-40 is a KCNQ2/3 potassium channels activator.QO-40 potently augmented KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V (1/2) ) in the hyperpolarizing direction. The V (1/2) was negatively shifted in a concentration-dependent manner.
CAS Number
1259536-70-3
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
377.75
Molecular Formula
C18H11ClF3N3O
Notes
Research use only, not for human use.
Receptor
KCNQ2/Q3 potassium channel

Chemical Information

5-(chloromethyl)-3-(naphthalen-1-yl)-2-(trifluoromethyl)-4H,7H-pyrazolo[1,5-a]pyrimidin-7-one
CAS Number1259536-70-3
PubChem CID51356808
IUPAC Name5-(chloromethyl)-3-naphthalen-1-yl-2-(trifluoromethyl)-1H-pyrazolo[1,5-a]pyrimidin-7-one
Molecular FormulaC18H11ClF3N3O
Molecular Weight377.7
XLogP3.8
Topological Polar Surface Area44.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count26
Formal Charge0
Complexity713
SMILES
C1=CC=C2C(=C1)C=CC=C2C3=C(NN4C3=NC(=CC4=O)CCl)C(F)(F)F
InChI
InChI=1S/C18H11ClF3N3O/c19-9-11-8-14(26)25-17(23-11)15(16(24-25)18(20,21)22)13-7-3-5-10-4-1-2-6-12(10)13/h1-8,24H,9H2
InChIKey
PAIKWVVGBGIKJH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-(chloromethyl)-3-(naphthalen-1-yl)-2-(trifluoromethyl)-4H,7H-pyrazolo[1,5-a]pyrimidin-7-one
CAS: 1259536-70-3
CID: 51356808
Formula: C18H11ClF3N3O
MW: 377.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight377.7
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass377.0542742
Monoisotopic Mass377.0542742
Topological Polar Surface Area44.7 Ų
Heavy Atom Count26
Formal Charge0
Complexity713
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA6930-50QO-40
A22616-10QO-40 10mg
A22616-50QO-40 50mg
A22616-200QO-40 200mg
A22616-100QO-40 100mg
A22616-25QO-40 25mg
A22616-5QO-40 5mg
A22616-10mM-DQO-40 10mM * 1mL in DMSO
GTR19196672QO-58
JAC53662-01QO 58

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