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ASP-5878

CAT: 1410-M20210-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M20210-02Size:1 mL x 10 mM in DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1 2 3 and 4 with IC50 values of 0.47 0.60 0.74 and 3.5 nmol/L.
CAS Number
1453208-66-6
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
407.38
Molecular Formula
C18H19F2N5O4
Notes
Research use only, not for human use.
Receptor
FGFR1/2/3/4

Chemical Information

Asp-5878

FGFR Inhibitor ASP5878 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR), with potential antineoplastic activity. Upon oral administration, FGFR inhibitor ASP5878 binds to and inhibits FGFR, which results in the inhibition of FGFR-mediated signal transduction pathways. This inhibits proliferation in FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation and survival.

CAS Number1453208-66-6
PubChem CID71736582
IUPAC Name2-[4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]pyrazol-1-yl]ethanol
Molecular FormulaC18H19F2N5O4
Molecular Weight407.4
XLogP1.2
Topological Polar Surface Area104
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Heavy Atom Count29
Formal Charge0
Complexity473
SMILES
COC1=CC(=C(C(=C1F)COC2=CN=C(N=C2)NC3=CN(N=C3)CCO)F)OC
InChI
InChI=1S/C18H19F2N5O4/c1-27-14-5-15(28-2)17(20)13(16(14)19)10-29-12-7-21-18(22-8-12)24-11-6-23-25(9-11)3-4-26/h5-9,26H,3-4,10H2,1-2H3,(H,21,22,24)
InChIKey
VDZZYOJYLLNBTD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Asp-5878
CAS: 1453208-66-6
CID: 71736582
Formula: C18H19F2N5O4
MW: 407.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight407.4
XLogP31.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Exact Mass407.14051043
Monoisotopic Mass407.14051043
Topological Polar Surface Area104 Ų
Heavy Atom Count29
Formal Charge0
Complexity473
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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