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ICRT 14

CAT: 1410-M18982-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M18982-07Size:100 mg
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Description
ICRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) (IC50= 40.3 nM in assays of Wnt pathway activity) .
CAS Number
677331-12-3
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
375.44
Molecular Formula
C21H17N3O2S
Notes
Research use only, not for human use.
Receptor
Wnt

Chemical Information

(5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione

ICRT14 is a member of thiazolidinediones. It has a role as a Wnt signalling inhibitor.

CAS Number677331-12-3
PubChem CID5967294
IUPAC Name(5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione
Molecular FormulaC21H17N3O2S
Molecular Weight375.4
XLogP4.1
Topological Polar Surface Area80.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity617
SMILES
CC1=CC(=C(N1C2=CN=CC=C2)C)/C=C\3/C(=O)N(C(=O)S3)C4=CC=CC=C4
InChI
InChI=1S/C21H17N3O2S/c1-14-11-16(15(2)23(14)18-9-6-10-22-13-18)12-19-20(25)24(21(26)27-19)17-7-4-3-5-8-17/h3-13H,1-2H3/b19-12-
InChIKey
NCSHZXNGQYSKLR-UNOMPAQXSA-N
Chemical Structure
2D Structure
2D structure of (5Z)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione
CAS: 677331-12-3
CID: 5967294
Formula: C21H17N3O2S
MW: 375.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight375.4
XLogP34.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass375.10414797
Monoisotopic Mass375.10414797
Topological Polar Surface Area80.5 Ų
Heavy Atom Count27
Formal Charge0
Complexity617
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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