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PJ34

CAT: 1410-M18454-04Size: 50 mgDry Ice: NoHazardous: No
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CAT#:1410-M18454-04Size:50 mg
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Description
PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
CAS Number
344458-19-1
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
295.34
Molecular Formula
C17H17N3O2
Notes
Research use only, not for human use.
Receptor
PARP1| PARP2

Chemical Information

PJ-34

PJ34 is a member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties. It has a role as an antiatherosclerotic agent, an antineoplastic agent, an angiogenesis inhibitor, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and a cardioprotective agent. It is a secondary carboxamide, a tertiary amino compound and a member of phenanthridines. It is a conjugate base of a PJ34(1+).

CAS Number344458-19-1
PubChem CID4858
IUPAC Name2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide
Molecular FormulaC17H17N3O2
Molecular Weight295.34
XLogP1.7
Topological Polar Surface Area61.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity438
SMILES
CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32
InChI
InChI=1S/C17H17N3O2/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22)
InChIKey
UYJZZVDLGDDTCL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PJ-34
CAS: 344458-19-1
CID: 4858
Formula: C17H17N3O2
MW: 295.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight295.34
XLogP31.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass295.132076794
Monoisotopic Mass295.132076794
Topological Polar Surface Area61.4 Ų
Heavy Atom Count22
Formal Charge0
Complexity438
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A3729-5PJ34
A4159-5.1PJ34 hydrochloride
A15215-25PJ34 25mg
A15215-10PJ34 10mg
MBS577330PJ34 HCl

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