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S- (+) -Rolipram

CAT: 1410-M17622-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1410-M17622-02Size:5 mg
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Description
S- (+) -Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.
CAS Number
85416-73-5
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
275.34
Molecular Formula
C16H21NO3
Notes
Research use only, not for human use.
Receptor
PDE4

Chemical Information

(S)-Rolipram

(+)-rolipram is the (S)-enantiomer of rolipram. It is an enantiomer of a (-)-rolipram.

CAS Number85416-73-5
PubChem CID158758
IUPAC Name(4S)-4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
Molecular FormulaC16H21NO3
Molecular Weight275.34
XLogP2.2
Topological Polar Surface Area47.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count20
Formal Charge0
Complexity341
SMILES
COC1=C(C=C(C=C1)[C@@H]2CC(=O)NC2)OC3CCCC3
InChI
InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m1/s1
InChIKey
HJORMJIFDVBMOB-GFCCVEGCSA-N
Chemical Structure
2D Structure
2D structure of (S)-Rolipram
CAS: 85416-73-5
CID: 158758
Formula: C16H21NO3
MW: 275.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight275.34
XLogP32.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass275.15214353
Monoisotopic Mass275.15214353
Topological Polar Surface Area47.6 Ų
Heavy Atom Count20
Formal Charge0
Complexity341
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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