Products for Research Use Only
RegisterLogin

MK-8591

CAT: 1410-M16284-06Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:1410-M16284-06Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MK-8591 (Islatravir, MK8591, EFdA) is a nucleoside analog that exhibits remarkable potency against wild-type and drug-resistant HIVs.
CAS Number
865363-93-5
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
293.25
Molecular Formula
C12H12FN5O3
Notes
Research use only, not for human use.
Receptor
HIV

Chemical Information

2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine

Islatravir is under investigation in clinical trial NCT04233216 (Doravirine/islatravir (DOR/ISL) in Heavily Treatment-experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)).

CAS Number865363-93-5
PubChem CID6483431
IUPAC Name(2R,3S,5R)-5-(6-amino-2-fluoropurin-9-yl)-2-ethynyl-2-(hydroxymethyl)oxolan-3-ol
Molecular FormulaC12H12FN5O3
Molecular Weight293.25
XLogP-0.6
Topological Polar Surface Area119
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity459
SMILES
C#C[C@]1([C@H](C[C@@H](O1)N2C=NC3=C(N=C(N=C32)F)N)O)CO
InChI
InChI=1S/C12H12FN5O3/c1-2-12(4-19)6(20)3-7(21-12)18-5-15-8-9(14)16-11(13)17-10(8)18/h1,5-7,19-20H,3-4H2,(H2,14,16,17)/t6-,7+,12+/m0/s1
InChIKey
IKKXOSBHLYMWAE-QRPMWFLTSA-N
Chemical Structure
2D Structure
2D structure of 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine
CAS: 865363-93-5
CID: 6483431
Formula: C12H12FN5O3
MW: 293.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight293.25
XLogP3-0.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass293.09241742
Monoisotopic Mass293.09241742
Topological Polar Surface Area119 Ų
Heavy Atom Count21
Formal Charge0
Complexity459
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
M16688-01MK-4101
M16496-01MK-8141
M16431-01MK 8776
M15329-01MK-212
M14568-01MK-0752
M12381-01MK-6169
M11576-01MK-8825
M10761-01MK-1064
M10626-01MK-8353
M10202-01MK-4074

Alternative Products

CatalogName
MBS3606281-01MK-8591
AR-A01459-01Adenosine Related Compound 6 (MK-8591)
AR-A05667-01Adenosine Related Compound 7 (MK-8591-TP)
AR-A01461-01Adenosine Related Compound 8 (MK-8591-TP)
324068-01MK
167912Midkine (MK, MK1, MK-1, MK 1) discontinued
152949B33C-2000-8591-WT Continuous Tapes for Printers
151414B33C-3000-8591-BK Continuous Tapes for Printers
MBS131426MK-4101 (MK 4101; MK4101)
152934B33C-2000-8591-YL Continuous Tapes for Printers

Popular Products