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KNK-437

CAT: 1410-M13492-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:1410-M13492-05Size:25 mg
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Description
An inhibitor of Heat shock protein (HSP) synthesis that dose-dependently inhibits the acquisition of thermotolerance and the induction of various HSPs including HSP105, HSP70, and HSP40 in human colon carcinoma cells.
CAS Number
218924-25-5
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
245.2307
Molecular Formula
C13H11NO4
Notes
Research use only, not for human use.
Receptor
HSP105|HSP40|HSP72

Chemical Information

Knk-437

inhibits thermotolerance acquisition and heat shock protein induction in colon carcinoma cells; structure in first source

CAS Number218924-25-5
PubChem CID46195007
IUPAC Name(3E)-3-(1,3-benzodioxol-5-ylmethylidene)-2-oxopyrrolidine-1-carbaldehyde
Molecular FormulaC13H11NO4
Molecular Weight245.23
XLogP1.5
Topological Polar Surface Area55.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count18
Formal Charge0
Complexity392
SMILES
C\1CN(C(=O)/C1=C/C2=CC3=C(C=C2)OCO3)C=O
InChI
InChI=1S/C13H11NO4/c15-7-14-4-3-10(13(14)16)5-9-1-2-11-12(6-9)18-8-17-11/h1-2,5-7H,3-4,8H2/b10-5+
InChIKey
LZGGUFLRKIMBDQ-BJMVGYQFSA-N
Chemical Structure
2D Structure
2D structure of Knk-437
CAS: 218924-25-5
CID: 46195007
Formula: C13H11NO4
MW: 245.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight245.23
XLogP31.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass245.06880783
Monoisotopic Mass245.06880783
Topological Polar Surface Area55.8 Ų
Heavy Atom Count18
Formal Charge0
Complexity392
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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