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Acrizanib

CAT: 1410-M10899-02Size: 1 mL x 10 mM in DMSODry Ice: NoHazardous: No
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CAT#:1410-M10899-02Size:1 mL x 10 mM in DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Acrizanib (LHA510, LHA-510) is a novel potent, selective VEGFR-2 (KDR) inhibitor with IC50 of 17.4 nM in cell-based assays.
CAS Number
1229453-99-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
445.406
Molecular Formula
C20H18F3N7O2
Notes
Research use only, not for human use.
Receptor
VEGFR

Chemical Information

Acrizanib

Acrizanib is under investigation in clinical trial NCT02355028 (LHA510 Proof-of-concept Study as a Maintenance Therapy for Patients With Wet Age-related Macular Degeneration).

CAS Number1229453-99-9
PubChem CID59394698
IUPAC Name5-[6-(methylaminomethyl)pyrimidin-4-yl]oxy-N-[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]indole-1-carboxamide
Molecular FormulaC20H18F3N7O2
Molecular Weight445.4
XLogP2.4
Topological Polar Surface Area98.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count32
Formal Charge0
Complexity655
SMILES
CNCC1=CC(=NC=N1)OC2=CC3=C(C=C2)N(C=C3)C(=O)NC4=NN(C(=C4)C(F)(F)F)C
InChI
InChI=1S/C20H18F3N7O2/c1-24-10-13-8-18(26-11-25-13)32-14-3-4-15-12(7-14)5-6-30(15)19(31)27-17-9-16(20(21,22)23)29(2)28-17/h3-9,11,24H,10H2,1-2H3,(H,27,28,31)
InChIKey
XPIHPLVWOUDMPF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Acrizanib
CAS: 1229453-99-9
CID: 59394698
Formula: C20H18F3N7O2
MW: 445.4
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight445.4
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass445.14740733
Monoisotopic Mass445.14740733
Topological Polar Surface Area98.9 Ų
Heavy Atom Count32
Formal Charge0
Complexity655
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA9048-5.1Acrizanib
A19384-5Acrizanib 5mg
A19384-100Acrizanib 100mg
EZB45399-01Acrizanib (LHA510)
A19384-10Acrizanib 10mg
A19384-1Acrizanib 1mg
A19384-50Acrizanib 50mg
A19384-25Acrizanib 25mg
A19384-10mM-DAcrizanib 10mM * 1mL in DMSO

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