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Acrizanib

CAT: 0931-T5373-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T5373-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1229453-99-9
Target
VEGFR
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Purity
0.9964
Bioactivity
Acrizanib (LHA510) is a VEGFR-2 inhibitor with an IC50 of 17.4 nM for BaF3-VEGFR-2.
Smiles
CNCc1cc(Oc2ccc3n(ccc3c2)C(=O)Nc2cc(n(C)n2)C(F)(F)F)ncn1
Molecular Formula
C20H18F3N7O2
Molecular Weight
445.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Acrizanib

Acrizanib is under investigation in clinical trial NCT02355028 (LHA510 Proof-of-concept Study as a Maintenance Therapy for Patients With Wet Age-related Macular Degeneration).

CAS Number1229453-99-9
PubChem CID59394698
IUPAC Name5-[6-(methylaminomethyl)pyrimidin-4-yl]oxy-N-[1-methyl-5-(trifluoromethyl)pyrazol-3-yl]indole-1-carboxamide
Molecular FormulaC20H18F3N7O2
Molecular Weight445.4
XLogP2.4
Topological Polar Surface Area98.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count32
Formal Charge0
Complexity655
SMILES
CNCC1=CC(=NC=N1)OC2=CC3=C(C=C2)N(C=C3)C(=O)NC4=NN(C(=C4)C(F)(F)F)C
InChI
InChI=1S/C20H18F3N7O2/c1-24-10-13-8-18(26-11-25-13)32-14-3-4-15-12(7-14)5-6-30(15)19(31)27-17-9-16(20(21,22)23)29(2)28-17/h3-9,11,24H,10H2,1-2H3,(H,27,28,31)
InChIKey
XPIHPLVWOUDMPF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Acrizanib
CAS: 1229453-99-9
CID: 59394698
Formula: C20H18F3N7O2
MW: 445.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight445.4
XLogP32.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass445.14740733
Monoisotopic Mass445.14740733
Topological Polar Surface Area98.9 Ų
Heavy Atom Count32
Formal Charge0
Complexity655
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA9048-5.1Acrizanib
A19384-5Acrizanib 5mg
A19384-100Acrizanib 100mg
EZB45399-01Acrizanib (LHA510)
A19384-10Acrizanib 10mg
A19384-1Acrizanib 1mg
A19384-50Acrizanib 50mg
A19384-25Acrizanib 25mg
A19384-10mM-DAcrizanib 10mM * 1mL in DMSO

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