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MK-1064

CAT: 1410-M10761-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M10761-06Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, selective, orally bioavailable Orexin 2 receptor (OX2R) antagonist with Ki/IC50 of 0.5/18 nM.
CAS Number
1207253-08-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
461.9003
Molecular Formula
C24H20ClN5O3
Notes
Research use only, not for human use.
Receptor
OX2

Chemical Information

Mk-1064

MK-1064 is under investigation in clinical trial NCT02549014 (A Single Dose Study of the Safety, Pharmacokinetics and Pharmacodynamics of MK-1064 (MK-1064-001)).

CAS Number1207253-08-4
PubChem CID44633765
IUPAC Name5-(5-chloro-3-pyridinyl)-N-[(5,6-dimethoxy-2-pyridinyl)methyl]-2-pyridin-2-ylpyridine-3-carboxamide
Molecular FormulaC24H20ClN5O3
Molecular Weight461.9
XLogP2.7
Topological Polar Surface Area99.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count33
Formal Charge0
Complexity629
SMILES
COC1=C(N=C(C=C1)CNC(=O)C2=C(N=CC(=C2)C3=CC(=CN=C3)Cl)C4=CC=CC=N4)OC
InChI
InChI=1S/C24H20ClN5O3/c1-32-21-7-6-18(30-24(21)33-2)14-29-23(31)19-10-16(15-9-17(25)13-26-11-15)12-28-22(19)20-5-3-4-8-27-20/h3-13H,14H2,1-2H3,(H,29,31)
InChIKey
CKTWQGHVNRYNCM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mk-1064
CAS: 1207253-08-4
CID: 44633765
Formula: C24H20ClN5O3
MW: 461.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight461.9
XLogP32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass461.1254672
Monoisotopic Mass461.1254672
Topological Polar Surface Area99.1 Ų
Heavy Atom Count33
Formal Charge0
Complexity629
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA5663-25MK-1064
A16360-100MK-1064 100mg
A16360-5MK-1064 5mg
A16360-2MK-1064 2mg
A16360-25MK-1064 25mg
A16360-1MK-1064 1mg
A16360-50MK-1064 50mg
A16360-10MK-1064 10mg
MBS579719MK-1064 (Urokinase inhibitor 1)
A16360-10mM-DMK-1064 10mM * 1mL in DMSO

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