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PL265

CAT: 1410-M10755Size: 1 EachDry Ice: NoHazardous: No
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Description
PL265 (PL-265) is a dual enkephalinase inhibitor, alleviate corneal pain and inflammation in vivo.
CAS Number
1206514-50-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
576.583
Molecular Formula
C28H37N2O9P
Notes
Research use only, not for human use.
Receptor
Neprilysin

Chemical Information

PL-265

a dual enkephalinase inhibitor of enzymes neprilysin (NEP) and aminopeptidase N (APN)

CAS Number1206514-50-2
PubChem CID44819606
IUPAC Name(2S)-2-[[(2S)-2-[[hydroxy-[(1R)-1-[1-(2-methylpropanoyloxy)ethoxycarbonylamino]ethyl]phosphoryl]methyl]-3-(4-phenylphenyl)propanoyl]amino]propanoic acid
Molecular FormulaC28H37N2O9P
Molecular Weight576.6
XLogP3.5
Topological Polar Surface Area168
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count15
Heavy Atom Count40
Formal Charge0
Complexity913
SMILES
C[C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=C(C=C1)C2=CC=CC=C2)CP(=O)([C@H](C)NC(=O)OC(C)OC(=O)C(C)C)O
InChI
InChI=1S/C28H37N2O9P/c1-17(2)27(34)38-20(5)39-28(35)30-19(4)40(36,37)16-24(25(31)29-18(3)26(32)33)15-21-11-13-23(14-12-21)22-9-7-6-8-10-22/h6-14,17-20,24H,15-16H2,1-5H3,(H,29,31)(H,30,35)(H,32,33)(H,36,37)/t18-,19+,20?,24+/m0/s1
InChIKey
ODSBYECYRZQRIK-LLHTUKDZSA-N
Chemical Structure
2D Structure
2D structure of PL-265
CAS: 1206514-50-2
CID: 44819606
Formula: C28H37N2O9P
MW: 576.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight576.6
XLogP33.5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count15
Exact Mass576.22366776
Monoisotopic Mass576.22366776
Topological Polar Surface Area168 Ų
Heavy Atom Count40
Formal Charge0
Complexity913
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19277374PL265
HY-115851Demethyl PL265

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