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D4476

CAT: 0804-HY-10324-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10324-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D4476 is a potent, selective and cell-permeable inhibitor of casein kinase 1 (CK1) with an IC50 value of 0.3 μM in vitro.
CAS Number
301836-43-1
Product Name Alternative
Casein Kinase I Inhibitor
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Casein Kinase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/D4476.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(N)C1=CC=C(C=C1)C(N2)=NC(C3=CC=C4OCCOC4=C3)=C2C5=NC=CC=C5
Molecular Formula
C23H18N4O3
Molecular Weight
398.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Rena G, et al. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 2004 Jan;5 (1) :60-5.|[2]Järås M, et al. Csnk1a1 inhibition has p53-dependent therapeutic efficacy?in?acute myeloid leukemia. J Exp Med.?2014 Apr 7;211 (4) :605-12.?
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1

Chemical Information

4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide

4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide is a member of imidazoles.

CAS Number301836-43-1
PubChem CID6419753
IUPAC Name4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
Molecular FormulaC23H18N4O3
Molecular Weight398.4
XLogP2.6
Topological Polar Surface Area103
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count30
Formal Charge0
Complexity597
SMILES
C1COC2=C(O1)C=CC(=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
InChI
InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
InChIKey
DPDZHVCKYBCJHW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(4-(2,3-dihydrobenzo(1,4)dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide
CAS: 301836-43-1
CID: 6419753
Formula: C23H18N4O3
MW: 398.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight398.4
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass398.13789045
Monoisotopic Mass398.13789045
Topological Polar Surface Area103 Ų
Heavy Atom Count30
Formal Charge0
Complexity597
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A3342-5.1D4476
A13949-500D4476 500mg
A13949-2D4476 2mg
A13949-1D4476 1mg
A13949-5D4476 5mg
A13949-200D4476 200mg
A13949-100D4476 100mg
A13949-50D4476 50mg
A13949-25D4476 25mg
A13949-10D4476 10mg

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