Products for Research Use Only
RegisterLogin

Apramycin (sulfate)

CAT: 0804-HY-B1329-01Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-B1329-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Apramycin (EBL 1003) sulfate is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin sulfate is a potential anti-drug-resistance antibiotic[1][2][3].
CAS Number
65710-07-8
Product Name Alternative
Nebramycin II (sulfate)
UNSPSC
12352005
Hazard Statement
H360
Target
Antibiotic; Bacterial
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Apramycin-sulfate.html
Purity
98.0
Solubility
H2O : ≥ 200 mg/mL
Smiles
O[C@H]1[C@](O[C@H](O[C@@]([C@H](C[C@H]2N)N)([H])[C@@H]([C@H]2O)O)[C@H](N)C3)([H])[C@@]3([H])O[C@H](O[C@@]([C@@H]([C@@H](O)[C@@H]4N)O)([H])O[C@@H]4CO)[C@H]1NC.O=S(O)(O)=O
Molecular Formula
C21H43N5O15S
Molecular Weight
637.66
Precautions
H360
References & Citations
[1]Juhas M, et al. In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii. J Antimicrob Chemother. 2019;74 (4) :944-952.|[2]Meyer M, et al. In vivo efficacy of apramycin in murine infection models. Antimicrob Agents Chemother. 2014 Nov;58 (11) :6938-41.|[3]Becker K, et al. Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis. EBioMedicine. 2021 Nov;73:103652.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
Phase 1
Isoform
Aminoglycoside
Citation 01
Acta Pharm Sin B. 2023 Sep;13 (9) :3678-3693.|Nat Microbiol. 2023 Mar;8 (3) :410-423.|Nat Microbiol. 2025 Nov;10 (11) :2875-2891.|J Adv Res. 2024 Jun 27:S2090-1232 (24) 00256-X.

Related Products

CatalogName
HY-17558Apramycin
HY-17558RApramycin (Standard)
HY-W460871SApramycin-d7 (acetate)
HY-166875SApramycin acetate-d7 (acetate)
HY-116282J-01Dextran sulfate, low sulfate (MW 5000)
HY-116282P-01Dextran sulfate, high sulfate (MW 5000)
HY-116282M-01Dextran sulfate, low sulfate (MW 40000)
HY-16955A-01Plazomicin (sulfate)
HY-111355-01Cholesterol sulfate
HY-W001273Pramiracetam (sulfate)

Alternative Products

CatalogName
B1665-50Apramycin Sulfate

Popular Products