Apramycin

Apramycin

• CAS Number: 37321-09-8
• UNSPSC Description: Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value: Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria.
• Target Antigen: Antibiotic; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/apramycin.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@H]1[C@](O[C@H](O[C@@]([C@H](C[C@H]2N)N)([H])[C@@H]([C@H]2O)O)[C@H](N)C3)([H])[C@@]3([H])O[C@H](O[C@@]([C@@H]([C@@H](O)[C@@H]4N)O)([H])O[C@@H]4CO)[C@H]1NC
• Molecular Weight: 539.58
• References & Citations: [1]Apramycin, From WikipediaJ Adv Res. 2024 Jun 27:S2090-1232(24)00256-X.|Acta Pharm Sin B. 2023 Jun 9.|Nat Microbiol. 2023 Mar;8(3):410-423.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported