α-Conotoxin EIIB

• UNSPSC Description:

  α-Conotoxin EIIB (Alpha-conotoxin EIIB) is a toxin peptide that can be obtained from Conus ermineus. α-Conotoxin EIIB binds to nAChR (Ki=2.2 nM). α-Conotoxin EIIB can be used in the study of neurological diseases such as schizophrenia, drug addiction, Alzheimer's disease, and Parkinson's disease[1].

• Target Antigen:

  nAChR

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C(N1)CCC1=O)N[C@H](C(N2[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H]4C)=O)CCC3)=O)CC5=CNC=N5)=O)CC6=CNC7=CC=CC=C67)=O)CSSC[C@H](NC8=O)C(N)=O)=O)CSSC[C@H](NC4=O)C(NCC(N[C@H](C(N[C@H](C(N[C@H]8CCCNC(N)=N)=O)CC(N)=O)=O)CCCCN)=O)=O)=O)=O)CC(O)C2)=O)[C@@H](C)O

• Molecular Weight:

  1754.99

• References & Citations:

  [1]Echterbille J, et al. Discovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry. Toxicon. 2017 May;130:1-10.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported