Mink IL-1 alpha Recombinant Protein

• Background:

  IL-1α is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. The IL-1 family of cytokines encompasses eleven proteins that each share a similar β-barrel structure and bind to Ig-like receptors. Several of the well characterized members of the IL-1-like cytokines play key roles in the development and regulation of inflammation. IL-1α, IL-1β, and IL-18 (IL-1F4) are well-known inflammatory cytokines active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. In contrast, IL-1 receptor antagonist (IL-1ra; IL-1F3) and IL-36 receptor antagonist (IL-36ra; IL-1F5) reduce inflammation by blocking the binding of the agonist receptor ligands. IL-33 (IL-1F11) is thought to function as an 'alarmin' released following cell necrosis to alerting the immune system to tissue damage or stress. The biological properties of IL-37 (IL-1F7) are mainly those of down-regulating inflammation.

• Description:

  The Mink IL-1 alpha yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Mink IL-1 alpha applications are for cell culture, ELISA standard, and Western Blot Control. Mink IL-1 alpha yeast-derived recombinant protein can be purchased in multiple sizes. Mink IL-1 alpha Specifications: (Molecular Weight: 18.1 kDa) (Amino Acid Sequence: SAAYNFRSNE KYNYMRIIKS QFILNDNLNQ SIIQQTGGNY LMAAALQNLD DAVKFDMGAY TSEDSKYPVT LRISKTRLFV SAQNEGEPVL LKEMPETPKT IKDETNLLFF WERHGTKNYF TSVAQPKLFI ATQERKLVHM ARGQPSITDF QILETQT (157) ) (Gene ID: 122915761) . For research use only.

• Applications:

  Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control

• Homology:

  Neogale vison (American mink)

• Storage Temperature:

  -20°C