Swine IFN lambda 3 (IL-28B) Recombinant Protein

• Background:

  IL-28B, IL-28A, and IL-29 are three closely related IFN-lambda cytokines that can be induced by viral infection that induce signaling through the Jak/STAT pathway. IL-28B, and other IFN-lambda cytokines, are well established as having several antiviral and anti-cancer activities. IFN-lambda, restricts virus from spreading into the brain and plays a major role in chronic viral infections found in the gastrointestinal tract. IL-28B, like other IFN-lambda cytokines, modulates innate and adaptive immunity, autoimmunity, and tumor progression. Unlike type I IFNs, which are able to stimulate most cell types, IL-28B, along with the other IFN-lambda cytokines, stimulation appears to be limited to dendritic cells and some tumor cell lines. Due to the affect IL-28B has on the adaptive immune system, it has gained much interest as an immunotherapeutic agent for treatment of allergic asthma. The IL-28 cytokines control T cell responses in vivo through the modulation of lung CD11c (+) DC function in experimental allergic asthma animal models. IFN-lambda cytokines, including IL-28B, have been shown to interact with a heterodimeric, class II cytokine receptor that consists of the IL-10 receptor, beta (IL-10RB) and the IL-28 receptor, alpha (IL-28RA) subunits. The promiscuous IL-10RB subunit is also common to IFN-alpha/beta family members, but the IL-28RA subunit is specific for the IFN-lambda cytokines, IL-28B, IL-28A, and IL-29.

• Description:

  The Swine IL-28B yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Swine IL-28B applications are for cell culture, ELISA standard, and Western Blot Control. Swine IL-28B yeast-derived recombinant protein can be purchased in multiple sizes. Swine IL-28B Specifications: (Molecular Weight: 19.2 kDa) (Amino Acid Sequence: VPVPEALRAL PGARGCHLAQ FKSLSPQALQ AFKRAKDAFE ESLLEDWNCS SRIFPRSRDL KQLQVWERPV ALEAEVALTL SVLGSLANSS LHSSLDQPLH TLRHIHAQLQ ACVPAQPMAG PRPRGRLHHW LHRLQEAQKK EPQSCLEASV MFNLFRLLTR DLKCVASGDL CV (172) ) (Gene ID: 100310828) . For research use only.

• Applications:

  Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control

• Homology:

  Phacochoerus africanus (Common warthog), Sus scrofa (pig)

• Storage Temperature:

  -20°C