BTB-1

CAT: 0804-HY-101770-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101770-01Size:5 mg
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Description
BTB-1 is a potent, selective and reversible mitotic motor protein Kif18A inhibitor with an IC50 of 1.69 μM.
CAS Number
[86030-08-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Kinesin; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BTB-1.html
Purity
99.91
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=S(C1=CC=C(Cl)C=C1[N+]([O-])=O)(C2=CC=CC=C2)=O
Molecular Formula
C12H8ClNO4S
Molecular Weight
297.71
Precautions
H302, H315, H319, H335
References & Citations
[1]Catarinella M, et al. BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl. 2009;48 (48) :9072-6.|[2]Braun J, et al. Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A. ACS Chem Biol. 2015 Feb 20;10 (2) :554-60.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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A19322-10BTB-1 10mg
A19322-50BTB-1 50mg
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