Mefenamic acid

• Description :

  Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1 and hCOX-2, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  COX

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/mefenamic-acid.html

• Purity :

  99.97

• Solubility :

  DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)

• Smiles :

  O=C(O)C1=CC=CC=C1NC2=CC=CC(C)=C2C

• Molecular Formula :

  C15H15NO2

• Molecular Weight :

  241.29

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2) :479-84.|[2]Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz) . 2016 Sep;17 (3) :219-25.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  COX-1; COX-2

• CAS Number :

  [61-68-7]