GDNF Human

• Description:

  GDNF Human_x000D_ Catalog number: B2018847_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 1 μg_x000D_ Molecular Weight or Concentration: ~15 kDa_x000D_ Supplied as: Powder_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -20°C_x000D_ Keywords: Glial cell-derived neurotrophic factor, GDNF_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Baloh RH, Johnson JP, Avalos P, Allred P, Svendsen S, Gowing G, Roxas K, Wu A, Donahue B, Osborne S, Lawless G, Shelley B, Wheeler K, Prina C, Fine D, Kendra-Romito T, Stokes H, Manoukian V, Muthukumaran A, Garcia L, Bañuelos MG, Godoy M, Bresee C, Yu H, Drazin D, Ross L, Naruse R, Babu H, Macklin EA, Vo A, Elsayegh A, Tourtellotte W, Maya M, Burford M, Diaz F, Patil CG, Lewis RA, Svendsen CN. Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial Nat Med. 2022 Sep;28(9):1813-1822._x000D_ 2: Gash DM, Gerhardt GA, Bradley LH, Wagner R, Slevin JT. GDNF clinical trials for Parkinson's disease: a critical human dimension Cell Tissue Res. 2020 Oct;382(1):65-70._x000D_ 3: Allen SJ, Watson JJ, Shoemark DK, Barua NU, Patel NK. GDNF, NGF and BDNF as therapeutic options for neurodegeneration Pharmacol Ther. 2013 May;138(2):155-75._x000D_ 4: Laperle AH, Moser VA, Avalos P, Lu B, Wu A, Fulton A, Ramirez S, Garcia VJ, Bell S, Ho R, Lawless G, Roxas K, Shahin S, Shelest O, Svendsen S, Wang S, Svendsen CN. Human iPSC-derived neural progenitor cells secreting GDNF provide protection in rodent models of ALS and retinal degeneration Stem Cell Reports. 2023 Aug 8;18(8):1629-1642._x000D_ 5: Shahin S, Tan P, Chetsawang J, Lu B, Svendsen S, Ramirez S, Conniff T, Alfaro JS, Fernandez M, Fulton A, Laperle AH, Svendsen CN, Wang S. Human Neural Progenitors Expressing GDNF Enhance Retinal Protection in a Rodent Model of Retinal Degeneration Stem Cells Transl Med. 2023 Nov 3;12(11):727-744._x000D_ 6: Ayanlaja AA, Zhang B, Ji G, Gao Y, Wang J, Kanwore K, Gao D. The reversible effects of glial cell line-derived neurotrophic factor (GDNF) in the human brain Semin Cancer Biol. 2018 Dec;53:212-222._x000D_ 7: Dong C, Ubogu EE. GDNF enhances human blood-nerve barrier function in vitro via MAPK signaling pathways Tissue Barriers. 2018;6(4):1-22._x000D_ 8: Eslamboli A. Assessment of GDNF in primate models of Parkinson's disease: comparison with human studies Rev Neurosci. 2005;16(4):303-10._x000D_ 9: Yin J, Chang HM, Yi Y, Yao Y, Leung PCK. TGF-β1 Increases GDNF Production by Upregulating the Expression of GDNF and Furin in Human Granulosa-Lutein Cells Cells. 2020 Jan 10;9(1):185._x000D_ 10: Cintrón-Colón AF, Almeida-Alves G, Boynton AM, Spitsbergen JM. GDNF synthesis, signaling, and retrograde transport in motor neurons Cell Tissue Res. 2020 Oct;382(1):47-56. _x000D_ _x000D_ Products Related to GDNF Human can be found at Proteins

• Short Description:

  Catalog Number: B2018847 (1 μg)_x000D_ GDNF is a protein essential for the survival of specific neurons, particularly dopaminergic neurons involved in movement. It is produced by glial cells and plays a role in neuroprotection and neuron growth. GDNF is also important in kidney development and maintaining the enteric nervous system. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5