Products for Research Use Only
RegisterLogin

Helenalin

CAT: 0804-HY-119970-01Size: 500 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-119970-01Size:500 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding[1][2].
CAS Number
6754-13-8
UNSPSC
12352005
Hazard Statement
H301
Target
NF-κB
Type
Natural Products
Related Pathways
NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/helenalin.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@]2([H])C(C(O[C@@]2(C[C@H]([C@@]([H])([C@]13C)C=CC3=O)C)[H])=O)=C
Molecular Formula
C15H18O4
Molecular Weight
262.31
Precautions
H301
References & Citations
[1]Merrill JC, et al. Role of glutathione in the toxicity of the sesquiterpene lactones hymenoxon and helenalin. J Toxicol Environ Health. 1988;23 (2) :159-69.|[2]Lyss G, et al. The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65. J Biol Chem. 1998 Dec 11;273 (50) :33508-16.|[3]Fernandes KM, et al. Helenalin-mediated post-transcriptional regulation of p21 (Cip1) inhibits 3T3-L1 preadipocyteproliferation. J Cell Biochem. 2008 Oct 15;105 (3) :913-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
451732-01Helenalin
GTR19230335-01Helenalin tiglate
GTR19197540Helenalin Acetate
M390048-epi-helenalin

Popular Products