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DNase-I Polyclonal Antibody

CAT: 0866-RD90752A-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0866-RD90752A-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations in DNase1 gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. DNase1 is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity.
Description
This is a DNase-I Polyclonal antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
Deoxyribonuclease-1, Deoxyribonuclease I, DNase I, Dornase alfa, DNASE1, DNL1, DRNI
Swiss Prot
P24855
Reactivity
Human
Immunogen
Recombinant Human DNase-I protein expressed by? Mammalian
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal antibody
Applications
WB
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:1000
Buffer
PBS with 0.02% sodium azide,50% glycerol pH 7.4
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
37kDa
Observed Molecular Weight
38-45kDa
Host or Source
Rabbit
Isotype
IgG

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