β-Aminopropionitrile (hydrochloride)

β-Aminopropionitrile (hydrochloride)

• CAS Number: 646-03-7
• UNSPSC Description: β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes[1][2].
• Target Antigen: Endogenous Metabolite; Monoamine Oxidase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Cancer; Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/β-aminopropionitrile-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: NCCC#N.Cl
• Molecular Weight: 106.55
• References & Citations: [1]Miana M, et al. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Dis Model Mech. 2015 Jun;8(6):543-51.|[2]Yang X, et al. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncol Rep. 2013 Feb;29(2):541-8.|[3]Ren W, et al. β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice. Sci Rep. 2016 Jun 22;6:28149.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported