PIK-C98

CAT: 0804-HY-12491Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-12491Size:1 Each
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Description
PIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 μM for α, β, δ, and γ isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma[1].
CAS Number
[691388-62-2]
UNSPSC
12352005
Target
Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pik-c98.html
Smiles
N#C/C(C(N)=S)=C\C=C\C1=CC=C(C2=C(Cl)C=CC(Cl)=C2)O1
Molecular Formula
C16H10Cl2N2OS
Molecular Weight
349.23
References & Citations
[1]Zhu J, et, al. A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma. Oncotarget. 2015 Jan 1;6 (1) :185-95.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

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