PIK-C98

• Description:

  PIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 μM for α, β, δ, and γ isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; PI3K

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pik-c98.html

• Smiles:

  N#C/C(C(N)=S)=C\C=C\C1=CC=C(C2=C(Cl)C=CC(Cl)=C2)O1

• Molecular Formula:

  C16H10Cl2N2OS

• Molecular Weight:

  349.23

• References & Citations:

  [1]Zhu J, et, al. A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma. Oncotarget. 2015 Jan 1;6 (1) :185-95.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

• CAS Number:

  [691388-62-2]