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AUTAC2

CAT: 0804-HY-134184-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134184-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC) . AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12[1].
CAS Number
2241669-08-7
UNSPSC
12352005
Target
AUTACs; Autophagy
Type
Reference compound
Related Pathways
Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/autac2.html
Purity
95.04
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](NC(C)=O)CSC1=NC2=C(N=C(N)NC2=O)N1CC3=CC=C(F)C=C3)NCCCOCCOCCOCCCNC(CCC(NC4=CC=CC([C@@H](CCC5=CC=C(OC)C(OC)=C5)OC([C@@H]6CCCCN6C(C(C(C)(CC)C)=O)=O)=O)=C4)=O)=O
Molecular Formula
C61H81FN10O14S
Molecular Weight
1229.42
References & Citations
[1]Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76 (5) :797-810.e10.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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