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ASP5878

CAT: 0127-BUP04746-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0127-BUP04746-02Size:5 mg
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CAS Number
1453208-66-6
Synonyms
ASP-5878
Purity
=98%
Smiles
COc1cc(OC)c(F)c(COc2cnc(Nc3cnn(CCO)c3)nc2)c1F

Chemical Information

Asp-5878

FGFR Inhibitor ASP5878 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR), with potential antineoplastic activity. Upon oral administration, FGFR inhibitor ASP5878 binds to and inhibits FGFR, which results in the inhibition of FGFR-mediated signal transduction pathways. This inhibits proliferation in FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, plays a key role in cellular proliferation and survival.

CAS Number1453208-66-6
PubChem CID71736582
IUPAC Name2-[4-[[5-[(2,6-difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]pyrazol-1-yl]ethanol
Molecular FormulaC18H19F2N5O4
Molecular Weight407.4
XLogP1.2
Topological Polar Surface Area104
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Heavy Atom Count29
Formal Charge0
Complexity473
SMILES
COC1=CC(=C(C(=C1F)COC2=CN=C(N=C2)NC3=CN(N=C3)CCO)F)OC
InChI
InChI=1S/C18H19F2N5O4/c1-27-14-5-15(28-2)17(20)13(16(14)19)10-29-12-7-21-18(22-8-12)24-11-6-23-25(9-11)3-4-26/h5-9,26H,3-4,10H2,1-2H3,(H,21,22,24)
InChIKey
VDZZYOJYLLNBTD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Asp-5878
CAS: 1453208-66-6
CID: 71736582
Formula: C18H19F2N5O4
MW: 407.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight407.4
XLogP31.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Exact Mass407.14051043
Monoisotopic Mass407.14051043
Topological Polar Surface Area104 Ų
Heavy Atom Count29
Formal Charge0
Complexity473
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA8938-25ASP5878
GTR19223910-01ASP5878 HCl
A20611-100ASP5878 100mg
A20611-10ASP5878 10mg
A20611-1ASP5878 1mg
A20611-50ASP5878 50mg
A20611-25ASP5878 25mg
A20611-5ASP5878 5mg

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