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ARRY-382

CAT: 0127-BUP02454-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0127-BUP02454-06Size:100 mg
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CAS Number
1313407-95-2
Purity
=98%
Smiles
N(C(=O)C=1N2C(=NC1)C=C(OCCN3CCN(C)CC3)C=C2)C4=C5C(=NN(CC=6N=C(C)C=CC6)C5=CC=C4)C7CC7

Chemical Information

Arry-382

cFMS Tyrosine Kinase Inhibitor ARRY-382 is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation.

CAS Number1313407-95-2
PubChem CID67259771
IUPAC NameN-[3-cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamide
Molecular FormulaC32H36N8O2
Molecular Weight564.7
XLogP3.9
Topological Polar Surface Area92.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Heavy Atom Count42
Formal Charge0
Complexity913
SMILES
CC1=NC(=CC=C1)CN2C3=CC=CC(=C3C(=N2)C4CC4)NC(=O)C5=CN=C6N5C=CC(=C6)OCCN7CCN(CC7)C
InChI
InChI=1S/C32H36N8O2/c1-22-5-3-6-24(34-22)21-40-27-8-4-7-26(30(27)31(36-40)23-9-10-23)35-32(41)28-20-33-29-19-25(11-12-39(28)29)42-18-17-38-15-13-37(2)14-16-38/h3-8,11-12,19-20,23H,9-10,13-18,21H2,1-2H3,(H,35,41)
InChIKey
JUPOTOIJLKDAPF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Arry-382
CAS: 1313407-95-2
CID: 67259771
Formula: C32H36N8O2
MW: 564.7
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight564.7
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Exact Mass564.29612242
Monoisotopic Mass564.29612242
Topological Polar Surface Area92.8 Ų
Heavy Atom Count42
Formal Charge0
Complexity913
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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