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SU4312

CAT: 0127-BUP00216-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0127-BUP00216-01Size:1 mg
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CAS Number
5812-07-7
Synonyms
SU 4312, NSC 86429
Purity
=95%
Smiles
CN(C)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1

Chemical Information

3-(4-Dimethylaminobenzylidenyl)-2-indolinone

SU4312 is a member of the class of oxindoles that is 3-methyleneoxindole in which one of the hydrogens of the methylene group has been replaced by a p-(dimethylamino)phenyl group. SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor. It also inhibits the neuronal nitric oxide synthase (NOS) and exhibits neuroprotection against NO-mediated neurotoxicity. It has a role as a geroprotector, an antineoplastic agent, an angiogenesis inhibitor, a neuroprotective agent and a vascular endothelial growth factor receptor antagonist. It is a member of oxindoles, a substituted aniline and a tertiary amino compound.

CAS Number5812-07-7
PubChem CID3135
IUPAC Name3-[[4-(dimethylamino)phenyl]methylidene]-1H-indol-2-one
Molecular FormulaC17H16N2O
Molecular Weight264.32
XLogP3
Topological Polar Surface Area32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity394
SMILES
CN(C)C1=CC=C(C=C1)C=C2C3=CC=CC=C3NC2=O
InChI
InChI=1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)
InChIKey
UAKWLVYMKBWHMX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(4-Dimethylaminobenzylidenyl)-2-indolinone
CAS: 5812-07-7
CID: 3135
Formula: C17H16N2O
MW: 264.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight264.32
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass264.126263138
Monoisotopic Mass264.126263138
Topological Polar Surface Area32.3 Ų
Heavy Atom Count20
Formal Charge0
Complexity394
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3847169-01SU4312
A22671-25SU4312 25mg
GTR19170290-01(Z) -SU4312
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A22671-10SU4312 10mg
A22671-2SU4312 2mg
HY-100349A-01Cis-SU4312
A22671-100SU4312 100mg
A22671-50SU4312 50mg
A22671-5SU4312 5mg

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