cRIPGBM (chloride)
CAT:
804-HY-115630-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
cRIPGBM (chloride)
- CAS Number: 2361988-77-2
- UNSPSC Description: cRIPGBM chloride, an orally active, proapoptotic derivative. cRIPGBM can be generated from glioblastoma multiforme (GBM) cancer stem cells (CSCs). cRIPGBM(chloride) targets to receptor-interacting protein kinase 2 (RIPK2) to induce caspase 1-dependent apoptosis. cRIPGBM(chloride) suppresses the formation of RIPK2/TAK1 (prosurvival complex), and increases the formation of RIPK2/caspase 1 (proapoptotic complex). cRIPGBM(chloride) exerts potent anti-tumor activity in vivo in animal models[1].
- Target Antigen: Apoptosis; Caspase; RIP kinase
- Type: Reference compound
- Related Pathways: Apoptosis
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/cripgbm-chloride.html
- Purity: 99.73
- Solubility: DMSO : 25 mg/mL (ultrasonic)|DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C(C1=C2[N+](CC3=CC=C(F)C=C3)=C(C)N1CC4=CC=CC=C4)C5=C(C=CC=C5)C2=O.[Cl-]
- Molecular Weight: 446.90
- References & Citations: [1]Lucki NC, et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6435-6440.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported