AICAR (phosphate)

• UNSPSC Description:

  AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism, and inhibits proinflammatory cytokines and iNOS production. AICAR phosphate is also an autophagy, YAP and mitophagy inhibitor[1][2].

• Target Antigen:

  AMPK; Autophagy; Endogenous Metabolite; Mitophagy; YAP

• Type:

  Natural Products

• Related Pathways:

  Autophagy;Epigenetics;Metabolic Enzyme/Protease;PI3K/Akt/mTOR;Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/AICAR-phosphate.html

• Smiles:

  OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC(C(N)=O)=C2N)O1.O=P(O)(O)O

• Molecular Weight:

  356.23

• References & Citations:

  [1]Nakamaru K, et al. AICAR, an activator of AMP-activated protein kinase, down-regulates the IR expression in HepG2 cells. Biochem Biophys Res Commun. 2005 Mar 11;328(2):449-54|[2]Drake JC, et al. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1546-54.|[3]Pold R, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats.Diabetes. 2005 Apr;54(4):928-34.|[4]Giri S, et al. 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J Neurosci. 2004 Jan 14;24(2):479-87.|[5]Ajaybabu V Pobbati, et al. A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy. Theranostics. 2020 Feb 18;10(8):3622-3635.Am J Chin Med. 2020;48(7):1693-1713.|J Cell Mol Med. 2023 Mar 23.|J Ethnopharmacol. 2023 Jun 3, 116731.|Research Square Preprint. 2021 Aug.|Research Square Print. December 19th, 2022.|Acta Biochim Biophys Sin (Shanghai). 2018 Feb 1;50(2):144-155.|Acta Biochim Biophys Sin (Shanghai). 2021 Jan 12;53(1):112-118.|Acta Cardiol. 2022 Oct 5;1-13.|Adipocyte. 2022 Dec;11(1):562-571.|Antioxid Redox Signal. 2023 Apr 13.|Antiviral Res. 2023 Jan 13;211:105542.|Aquaculture Reports. 2023 Jun, 30, 101549.|Aquaculture. 2025 Jan 15.|Arab J Chem. 2024 Aug.|Arch Biochem Biophys. 2023 Jul 8;109689.|Arch Toxicol. 2019 Jun;93(6):1697-1712. |Authorea. September 07, 2022.|Biochem Biophys Res Commun. 2023 Jul 6.|Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3723-3738. |Biochim Biophys Acta Mol Basis Dis. 2022 Feb 15;1868(5):166369.|Biochim Biophys Acta Mol Basis Dis. 2024 Jun 25:167314.|Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Nov 27:159428.|Biochim Biophys Acta Mol Cell Res. 2022 Aug;1869(8):119265.|Biomed Environ Sci. 2019 Dec;32(12):944-948.|Biomed Pharmacother. 2023 May 27;164:114907.|Biomedicines. 2022, 10(1), 165.|bioRxiv. 2021 Jan 31.|bioRxiv. 2024 May 25.|Br J Cancer. 2023 Feb 21.|Cancer Cell. 2020 Sep 14;38(3):350-365.e7.|Cancer Res. 2023 Sep 22.|Cardiovasc Toxicol. 2024 Aug 13.|Cell Biol Int. 2023 Jul 20.|Cell Biol Int. 2023 Sep 26.|Cell Commun Signal. 2023 May 4;21(1):99.|Cell Death Differ. 2021 Apr;28(4):1222-1236.|Cell Death Dis. 2018 May 1;9(5):515.|Cell Death Dis. 2021 May 18;12(6):506.|Cell Death Dis. 2024 Sep 30;15(9):697.|Cell Death Discov. 2024 Jan 17;10(1):34.|Cell Metab. 2019 Jul 2;30(1):157-173.e7|Cell Mol Biol Lett. 2022 Aug 9;27(1):66.|Cell Rep. 2021 Sep 21;36(12):109739.|Cell Rep. 2022 Aug 16;40(7):111204.|Cell Rep. 2022 Nov 22;41(8):111707.|Cell Signal. 2024 Mar 1:111125.|Cell Signal. 22 October 2022, 110502.|Cells. 2022, 11(17), 2706.|Clin Transl Med. 2020 Oct;10(6):e205.|Clin Transl Med. 2022 Mar;12(3):e777.|Curr Eye Res. 2022 May 25;1-13.|Curr Res Food Sci. 2024 Mar 28:8:100728.|Ecotoxicol Environ Saf. 2023 Dec 14:115831.|Endocr J. 2021 Oct 29.|Environ Pollut. 2023 Feb 7;322:121202.|Enzyme Microb Tech. 2020, 109737.|Eur J Pharmacol. 2024 Jun 5:972:176543.|Exp Eye Res. 2020 Apr;193:107972.|Exp Eye Res. 2024 Mar 5:241:109851.|Exp Ther Med. June 1, 2022.|FASEB J. 2020 Nov;34(11):14946-14959.|Food Chem Toxicol. 2023 Oct 5:181:114089.|Food Chem Toxicol. 2024 Jun 5:114790.|Food Funct. 2020 Apr 1;11(4):3073-3083.|Free Radic Biol Med. 2023 Feb 1;195:89-102.|Front Immunol. 08 November 2021.|Front Microbiol. 2020 Feb 28;11:320.|Front Pharmacol. 2018 Jul 16;9:761. |Front Pharmacol. 2020 Jul 31;11:1038.|Front Pharmacol. 2021 Jul 7;12:687394.|Front Pharmacol. 2022 May 13;13:887497.|Front Pharmacol. 2023 Apr 18:14:1148611.|Front Pharmacol. 2018 Apr 16;9:345.|Front Physiol. 27 October 2021.|Genes (Basel). 2022 Dec 16;13(12):2384.|Gut Microbes. 2024 Jan-Dec;16(1):2412381.|Heliyon. 2023 Nov 28, e22939.|Herald of Medicine. 2023 Jun, 42(6): 781-789.|Int Immunopharmacol. 2022 Aug 17;111:109165.|Int Immunopharmacol. 2022 Aug 4;111:109114.|Int Immunopharmacol. 2022 Feb 22;106:108600.|Int J Biol Macromol. 2023 Jul 12;125816.|Int J Biol Macromol. 2024 Feb 5;262(Pt 1):129950.|Int J Biol Sci. 2021 Jul 22;17(12):3091-3103.|Int J Biol Sci. 2024 Aug 19;20(11):4476-4495.|Int J Mol Med. 2018 Aug;42(2):799-810. |Int J Mol Med. 2018 May;41(5):2535-2544.|Int J Mol Med. 2023 Mar 13.|iScience. 2023 Jul 12;26(8):107295.|J Agric Food Chem. 2019 Jun 26;67(25):7060-7072.|J Agric Food Chem. 2021 Jul 29.|J Agric Food Chem. 2022 Aug 30.|J Agric Food Chem. 2024 May 8;72(18):10339-10354.|J Agric Food Chem. 2024 Sep 13.|J Anim Sci Biotechnol. 2023 Nov 2;14(1):141.|J Biol Chem. 2022 Oct 12;102587.|J Biol Chem. 2024 Jul 11:107549.|J Cardiovasc Pharmacol. 2022 May 1;79(5):730-738.|J Cell Mol Med. 2020 Aug;24(16):9135-9144.|J Cell Mol Med. 2021 Dec 28.|J Cell Physiol. 2018 Dec;233(12):9701-9715.|J Ethnopharmacol. 2023 Sep 8;117162.|J Exp Clin Cancer Res. 2021 Jun 23;40(1):206.|J Funct Foods. 2024 May, 116, 106168.|J Immunol Res. 2022 Feb 8;2022:2619781.|J Immunol. 2022 Oct 24;ji2200182.|J Integr Med. 2022 Apr 27;S2095-4964(22)00051-6.|J Leukoc Biol. 2021 Dec 20.|J Oncol. 17 Jul 2021.|J Orthop Surg Res. 2023 Jun 27;18(1):462.|J Photoch Photobio B. 2020 Dec;213:112075.|J Virol. 2024 Feb 6:e0175123.|JCI Insight. 2022 Jan 25;e154595.|Med Oncol. 2023 Dec 26;41(1):29.|Mol Biol Rep. 2019 Dec;46(6):6435-6451.|Mol Cell Biochem. 2020 Aug;471(1-2):91-100.|Mol Nutr Food Res. 2024 Jun 11:e2300915.|Neural Regen Res. 2024 Jun 26.|Nutr Res Pract. 2024 Aug;18(4):479-497.|Nutrients. 2020 Oct 19;12(10):3195.|Nutrients. 2021 May 21;13(6):1740.|Oncogene. 2019 Sep;38(38):6537-6549.|Oxid Med Cell Longev. 04 Oct 2022.|Oxid Med Cell Longev. 05 Aug 2022.|Pharmacol Res. 2021 Dec 1;175:105985.|Pharmacol Res. 2021 Mar 15;105561.|Pharmacol Res. 2023 Jan 16;188:106666.|Phytomedicine. 2021, 153526.|Phytomedicine. 2024 Mar 24, 155534.|Phytomedicine. 2024 Sep 30:135:156111.|Phytother Res. 2019 Jul;33(7):1794-1804. |Proc Natl Acad Sci U S A. 2024 Oct 29;121(44):e2321305121.|Redox Biol. 2021 Jul 26;46:102082.|Regen Biomater. 2024 Mar 1.|Res Sq. 2024 Jun 25.|Research Square Preprint. 2021 Sep.|Research Square Preprint. 2023 Jun 26.|Research Square Preprint. 2023 May 26.|Research Square Print. 2022 May.|Research Square Print. 2023 Jan 24.|Signal Transduct Target Ther. 2022 Feb 14;7(1):40.|Signal Transduct Target Ther. 2023 Mar 6;8(1):95.|SSRN. 2024 Sep 28.|Theriogenology. 2024 May 24:225:152-161.|Virus Genes. 2022 Mar 7.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  681006-28-0