Products for Research Use Only
RegisterLogin

TRAIL R-2/DR5, soluble

CAT: 0209-S01-036-L250Size: 250 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0209-S01-036-L250Size:250 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain", which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-2/DR5 is a 14.9 kDa protein (133 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.
Synonyms
TNFRSF10B; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5
NCBI Gene ID
8795
UniProt
O14763
Accession Number
NP_003833.4
Accession Number mRNA
NM_003842.4
Chromosomal Location
8p22-p21
Reactivity
Human
Cross Reactivity
Human
Sequence
MESALITQQD LAPQQRVAPQ QKRSSPSEGL CPPGHHISED GRDCISCKYG QDYSTHWNDL LFCLRCTRCD SGEVELSPCT TTRNTVCQCE EGTFREEDSP EMCRKCRTGC PRGMVKVGDC TPWSDIECVH KES
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
STRAIL Receptor 2 reduced the production of LPS-induced TNF by its ability to neutralize endogenous TRAIL in fresh human PBMC. In this assay, endogenous TRAIL is induced during a 24 hour exposure to LPS (10 ng/mL) but in the presence of sTRAIL Receptor 2, TRAIL-induced TNF is suppressed.
Length
133
Form
Lyophilized
Molecular Weight
14.9 kDa
Host or Source
E. coli

Related Products

CatalogName
S01-035STRAIL R-1/DR4, soluble
S01-035-L250TRAIL R-1/DR4, soluble
S01-035-L1000TRAIL R-1/DR4, soluble
S01-035TRAIL R-1/DR4, soluble
S01-035-L500TRAIL R-1/DR4, soluble
S01-035-L100TRAIL R-1/DR4, soluble
100-301STRAIL/Apo2L, soluble
100-301TRAIL/Apo2L, soluble
M10-128-L100TRAIL
M10-128-L1000TRAIL

Alternative Products

CatalogName
MBS691966-01Human TRAIL R-2/DR5, soluble
301346DR5 (TRAIL Receptor 2, KILLER, TRAIL Receptor-2, TRICK2A, Soluble TRAIL Receptor-2, TRAIL R2, TRICKB, TNFRSF10B, Apo-2L)
301346-HRPDR5 (TRAIL Receptor 2, KILLER, TRAIL Receptor-2, TRICK2A, Soluble TRAIL Receptor-2, TRAIL R2, TRICKB, TNFRSF10B, Apo-2L) (HRP)
301346-FITCDR5 (TRAIL Receptor 2, KILLER, TRAIL Receptor-2, TRICK2A, Soluble TRAIL Receptor-2, TRAIL R2, TRICKB, TNFRSF10B, Apo-2L) (FITC)
301346-APCDR5 (TRAIL Receptor 2, KILLER, TRAIL Receptor-2, TRICK2A, Soluble TRAIL Receptor-2, TRAIL R2, TRICKB, TNFRSF10B, Apo-2L) (APC)
301346-PEDR5 (TRAIL Receptor 2, KILLER, TRAIL Receptor-2, TRICK2A, Soluble TRAIL Receptor-2, TRAIL R2, TRICKB, TNFRSF10B, Apo-2L) (PE)
301346-BiotinDR5 (TRAIL Receptor 2, KILLER, TRAIL Receptor-2, TRICK2A, Soluble TRAIL Receptor-2, TRAIL R2, TRICKB, TNFRSF10B, Apo-2L) (Biotin)
MBS6452257-01DR5 (TRAIL Receptor 2, KILLER, TRAIL Receptor-2, TRICK2A, Soluble TRAIL Receptor-2, TRAIL R2, TRICKB, TNFRSF10B, Apo-2L) (AP)
301347DR5, NT (TRAIL Receptor 2, TRAIL-R2, KILLER, TRAIL Receptor-2, TNFRSF10B, Soluble TRAIL Receptor-2, TRICKB, TRAIL R2, TRICK2A) (Not for Export EU)
MBS692076-01Human TRAIL R-1/DR4, soluble

Popular Products