TL-1A (Animal Free)

• Description:

  TL‐1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in the placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL‐1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NF‐κB activation, caspase activity, and apoptosis in responding cell lines. TL‐1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6. Recombinant Human TL‐1A is a 22.1 kDa polypeptide of 195 amino acid residues.

• Synonyms:

  TNFSF15; TL1; TL1A; VEGI; VEGI192A

• NCBI Gene ID:

  9966

• UniProt:

  O95150

• Accession Number:

  NP_005109

• Accession Number mRNA:

  NM_005118

• Chromosomal Location:

  9q32

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  QLRAQGEASV QFQALKGQEF APSHQQVYAP LRADGDKPRA HLTVVRQTPT QHFKNQFPAL HWEHELGLAF TKNRMNYTNK FLLIPESGDY FIYSQVTFRG MTSECSEIRQ AGRPNKPDSI TVVITKVTDS YPEPTQLLMG TKSVCEVGSN WFQPIYLGAM FSLQEGDKLM VNVSDISLVD YTKEDKTFFG AFLL

• Endotoxin:

  < 0.01 ng/µg of protein (< 0.1 EU/µg)

• Purity:

  ≥ 98% by SDS-PAGE gel and HPLC analyses.

• Bioactivity:

  Determined by its ability to stimulate IFN-γ production by human PBMC co-stimulated with Human IL-12 and Human IL-18.

• Length:

  194

• Form:

  Lyophilized

• Molecular Weight:

  22 kDa

• Host or Source:

  E. coli