TGF-alpha

CAT: 0209-100-103-L1000Size: 1000 µgDry Ice: NoHazardous: No
CAT#:0209-100-103-L1000Size:1000 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TGF-α is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces transformation anchorage independence in cultured cells. Human, murine and rat TGF-α are cross-species reactive. Recombinant human TGF-α is a 50 amino acid polypeptide (5.5 kDa) which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.
Synonyms
TGFA; TFGA
NCBI Gene ID
7039
UniProt
P01135
Accession Number
NP_003227.1
Accession Number mRNA
NM_003236
Chromosomal Location
2p13
Reactivity
Human
Cross Reactivity
Chicken, Mouse, Rat, Human, Horse
Sequence
VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
Length
50
Form
Lyophilized
Molecular Weight
5.5 kDa
Host or Source
E. coli

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