RegisterLogin

TGF-beta2

CAT: 209-100-451-L2Size: 2 µgDry Ice: NoHazardous: No
2 µgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
Synonyms
TGFB2; TGF-beta2
NCBI Gene ID
7042
UniProt
P61812
Accession Number
NP_001129071
Accession Number mRNA
NM_001135599
Chromosomal Location
1q41
Reactivity
Human
Cross Reactivity
Mouse, Rat, Human, Sheep
Sequence
ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS
Assay Protocol
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at ‑20°C to -80°C.
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED50 was found to be ≤ 0.2 ng/ml (≥ 5 x 106 units/mg) .
Length
112
Form
Lyophilized
Buffer
Sodium Citrate, pH 3.5
Reconstitution
Water
Molecular Weight
25 kDa
Storage Conditions
The lyophilized protein is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 10 months at -20°C to -80°C.
Host or Source
HEK293 cells

Related Products

CatalogName
300-023STGF-beta1
102-P50TGF-beta3
300-023-L50TGF-beta1
300-023-L100TGF-beta1
300-023-L250TGF-beta1
100-107TGF-beta3
300-023-L1000TGF-beta1
300-023TGF-beta1
100-107STGF-beta3
300-023-L500TGF-beta1

Alternative Products

CatalogName
PR27165-BTGF Beta2
MBS692700-01TGF-beta2
529032-01TGF beta2
405118-01TGF beta2
PR27165-01TGF Beta2
336978TGF beta2 discontinued
MBS9600197-01TGF beta2 Antibody
5343R-100TGF-beta2 Antibody
MBS691654-01Human TGF-beta2
MBS9504737-01TGF beta2 Antibody

Popular Products