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RANKL (TRANCE), soluble

CAT: 0209-R20-020-L50Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0209-R20-020-L50Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant rat sRANKL is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino acid residues) .
Synonyms
Soluble Receptor Activator of NFkB Ligand, TNFSF11, TRANCE (TNF-related activation-induced cytokine), OPGL, ODF (Osteoclast differentiation factor), Tumor necrosis factor ligand superfamily member 11, tumor necrosis factor ligand superfamily member 11, osteoprotegerin ligand, receptor activator of nuclear factor kappa B ligand, receptor activator of nuclear factor kappa-B ligand
NCBI Gene ID
117516
UniProt
Q9ESE2
Accession Number
NP_476490.1
Accession Number mRNA
NM_057149.1
Chromosomal Location
15q11
Reactivity
Rat
Cross Reactivity
Mouse, Rat
Sequence
PAMMEGSWLD VARRGKPEAQ PFAHLTINAA DIPSGSHKVS LSSWYHDRGW AKISNMTLSN GKLRVNQDGF YYLYANICFR HHETSGSVPA DYLQLMVYVV KTSIKIPSSH NLMKGGSTKN WSGNSEFHFY SINVGGFFKL RAGEEISVQV SNPSLLDPDQ DATYFGAFKV QDID
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to induce NFkappaB in RAW264.7 cells in the absence of any cross-linking. The expected ED50 for this effect is 10.0-25.0 ng/ml.
Length
174
Form
Lyophilized
Molecular Weight
19.4 kDa
Host or Source
E. coli

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Alternative Products

CatalogName
044789RANKL, Soluble, Recombinant, Mouse, Fc (TRANCE, ODF, OPGL, TNFSF11, CD254)
MBS638325-01Fc:RANKL, Soluble, Recombinant, Mouse (TRANCE, ODF, OPGL, TNFSF11, CD254)
500418RANKL, Recombinant, Human (TNFSF11, Soluble Receptor Activator of NFkB Ligand, TRANCE, TNF-Related Activation-Induced Cytokine, OPGL, ODF, Osteoclast Differentiation Factor) discontinued
149724-01RANKL, Soluble, Recombinant, Rat (Tumor Necrosis Factor Ligand Superfamily Member 11, Osteoclast Differentiation Factor, ODF, Osteoprotegerin Ligand, OPGL, Receptor Activator of Nuclear Factor kappa-B Ligand, TNF-related Activation-induced Cytokine, TRANCE, CD254, Opgl, Rankl, Trance, Tnfsf11) discontinued. see 143509
MBS6496806-01RANKL, NT (Tumor Necrosis Factor Ligand Superfamily Member 11, Receptor Activator Of Nuclear Factor kappa-B Ligand, TNFSF11, TNF-related Activation-induced Cytokine, TRANCE, Tumor Necrosis Factor Ligand Superfamily Member 11, Soluble Form, Tumor Necrosis
207373-01RANKL, Soluble, Recombinant, Human, aa152-317 (Tumor Necrosis Factor Ligand Superfamily Member 11, CD254, Osteoclast Differentiation Factor, ODF, Osteoprotegerin Ligand, OPGL, Receptor Activator of Nuclear Factor kappa-B Ligand, TNFSF11, TNF-related Activation-induced Cytokine, TRANCE)
220214RANK, Recombinant, Human (sRANKL, Soluble Receptor Activator of NFkB Ligand, TNFSF11, TRANCE, TNF-related Activation-induced Cytokine, OPGL, ODF, Osteoclast Differentiation Factor, Tumor Necrosis Factor Ligand Superfamily Member 11, Receptor Activator of Nuclear Factor kappa B Ligand, RANKL, Osteoprotegerin Ligand, CD254 antigen, SOdf, hRANKL2) discontinued
R1075-10NRANKL, NT (Tumor Necrosis Factor Ligand Superfamily Member 11, Receptor Activator Of Nuclear Factor kappa-B Ligand, TNFSF11, TNF-related Activation-induced Cytokine, TRANCE, Tumor Necrosis Factor Ligand Superfamily Member 11, Soluble Form, Tumor Necrosis Factor Ligand Superfamily Member 11, Membrane Form, CD254, Osteoclast Differentiation Factor, ODF, Osteoprotegerin Ligand, OPGL)
R1075-10N-BiotinRANKL, NT (Tumor Necrosis Factor Ligand Superfamily Member 11, Receptor Activator Of Nuclear Factor kappa-B Ligand, TNFSF11, TNF-related Activation-induced Cytokine, TRANCE, Tumor Necrosis Factor Ligand Superfamily Member 11, Soluble Form, Tumor Necrosis Factor Ligand Superfamily Member 11, Membrane Form, CD254, Osteoclast Differentiation Factor, ODF, Osteoprotegerin Ligand, OPGL) (Biotin) discontinued
R1075-10N-APCRANKL, NT (Tumor Necrosis Factor Ligand Superfamily Member 11, Receptor Activator Of Nuclear Factor kappa-B Ligand, TNFSF11, TNF-related Activation-induced Cytokine, TRANCE, Tumor Necrosis Factor Ligand Superfamily Member 11, Soluble Form, Tumor Necrosis Factor Ligand Superfamily Member 11, Membrane Form, CD254, Osteoclast Differentiation Factor, ODF, Osteoprotegerin Ligand, OPGL) (APC) discontinued

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