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Osteoprotegerin (OPG)

CAT: 0209-100-089-L250Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0209-100-089-L250Size:250 µg
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Description
Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney, liver, spleen, prostate, lymph node and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG. Recombinant human OPG is a soluble 20.0 kDa protein containing 174 amino acid residues.
Synonyms
TNFRSF11B; OPG; TR1; OCIF
NCBI Gene ID
4982
UniProt
O00300
Accession Number
NP_002537.3
Accession Number mRNA
NM_002546.3
Chromosomal Location
8q24
Reactivity
Human
Cross Reactivity
Mouse, Rat, Human
Sequence
METFPPKYLHYDEETSHQLLCDKCPPGTYLKQHCTAKWKTVCAPCPDHYYTDSWHTSDECLYCSPVCKELQYVKQECNRTHNRVCECKEGRYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSVFGLLLTQKGNATHDNICSGNSESTQK
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to neutralize the stimulation of U937 cells treated with 10 ng/ml of soluble RANKL (sRANKL) .
Length
174
Form
Lyophilized
Molecular Weight
20 kDa
Host or Source
E. coli

UniProtKB · O00300

Tumor necrosis factor receptor superfamily member 11B

TR11B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O00300
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFRSF11B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2R9A8, O60236, Q53FX6, Q9UHP4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Apoptosis

Disease

Disease variant

PTM

Disulfide bondGlycoprotein

Molecular function

Receptor

Domain

RepeatSignal

Cellular component

Secreted

Related Products

CatalogName
102-P200OPG
600-271-L1000Osteoprotegerin / TNFRSF11B Protein (His Tag)
600-271-L100Osteoprotegerin / TNFRSF11B Protein (His Tag)
M60-170-L100Osteoprotegerin / TNFRSF11B Protein (hFc Tag)
600-270-L100Osteoprotegerin / TNFRSF11B Protein (hFc Tag)
M60-184-L50RANKL / OPGL / TNFSF11 / CD254 Protein (Fc Tag)
M60-184-L20RANKL / OPGL / TNFSF11 / CD254 Protein (Fc Tag)

Alternative Products

CatalogName
RC219-19OPG, Osteoprotegerin, human
MBS2162489-01Eukaryotic Osteoprotegerin (OPG)
MBS2125413-01Recombinant Osteoprotegerin (OPG)
abx007473-01Osteoprotegerin (Opg) Antibody
FY-AB51791-01Anti-Osteoprotegerin (OPG)
TRV-043536-01Active Osteoprotegerin (OPG)
QY-E40237Porcine Osteoprotegerin (OPG)
QY-E80217Chicken Osteoprotegerin (OPG)
MBS692098-01Human Osteoprotegerin (OPG)

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