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OPG

CAT: 0209-102-P200Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-102-P200Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. OPG is expressed in a wide variety of tissues including adult heart, lung, kidney, liver, spleen, prostate, lymph node and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which corresponds to the extracellular cysteine-rich domains of TNFR proteins and constitutes the soluble OPG. Recombinant human OPG is a soluble 20.0 kDa protein containing 174 amino acid residues.
Synonyms
TNFRSF11B; OPG; TR1; OCIF
NCBI Gene ID
4982
UniProt
O00300
Accession Number
NP_002537.3
Accession Number mRNA
NM_002546.3
Chromosomal Location
8q24
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant Human OPG
Clone
Rabbit IgG
Applications
ELISA, WB
Purification Method
Antigen-affinity purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Host or Source
Rabbit

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