NRG1-alpha Protein (ECD, His Tag)

• Description:

  Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

• Synonyms:

  ARIA Protein; GGF Protein; GGF2 Protein; HGL Protein; HRG Protein; HRG1 Protein; HRGA Protein; MST131 Protein; MSTP131 Protein; NDF Protein; NRG1-IT2 Protein; SMDF Protein

• Accession Number:

  Q02297-1

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Label:

  His-Tag

• Assay Protocol:

  See Datasheet send with the product

• Endotoxin:

  < 1.0 EU per μg protein as determined by the LAL method.

• Purity:

  > 98 % as determined by SDS-PAGE

• Bioactivity:

  1. Measured by its ability to biotinylated Human ErbB4-Fc in functional ELISA. 2. Measured by its ability to biotinylated Rhesus ErbB3-His in functional ELISA. 3. Measured by its ability to biotinylated Rhesus ErbB3 in functional ELISA.

• Length:

  233

• Form:

  Lyophilized or frozen liquid

• Buffer:

  PBS, pH 7.4

• Reconstitution:

  See Datasheet

• Molecular Weight:

  45 kDa (glycosylated)

• Storage Conditions:

  Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

• Host or Source:

  HEK 293 cells